A prostate biopsy involves the removal of small samples of suspicious tissues from the prostate. Prostate biopsy is recommended when the results of initial tests, such as prostate-specific antigen (PSA) blood test or digital rectal exam (DRE), raise concerns of possible cancer. The biopsy procedure is performed by a urologist. During the procedure a fine needle is used to collect tissue samples from the prostate gland. After the tissue samples are obtained, they are examined under a microscope for cell abnormalities which may denote prostate cancer. Biopsy also helps in evaluating the stage and type of cancer to assist the doctor in formulating the most appropriate treatment option.